City otherwise have a fully-fit squad with defender Aymeric Laporte available again after overcoming a knock.
Borussia Dortmund will be without winger Jadon Sancho, who has been ruled out of his reunion with his former club.
The England winger is back in training after six weeks out with a thigh injury but Wednesday's clash at Signal Iduna Park comes too soon.
Dortmund also have doubts over the experienced pair Marco Reus - goalscorer in the first leg - and World Cup-winner Mats Hummels.
Pep Guardiola has urged his Manchester City players to seize the moment and secure their place in the Champions League semi-finals.
City have suffered defeat in the last 16 and in three successive quarter-finals since Guardiola took charge of the club.